# Development of Clindamycin-Releasing Polyvinyl Alcohol Hydrogel with Self-Healing Property for the Effective Treatment of Biofilm-Infected Wounds
> Alifah N.

URL kanonis: https://discover.unhas.ac.id/publications/development-of-clindamycin-releasing-polyvinyl-alcohol-hydrogel-with-self-healin
Jurnal / Konferensi: Gels
Tahun terbit: 2024
DOI: https://doi.org/10.3390/gels10070482
ISSN: 23102861
Kuartil SJR: Q1
Citations: 14

## Authors
- Alifah N.

## Abstract
Self-healing hydrogels have good mechanical strength, can endure greater external force, and have the ability to heal independently, resulting in a strong bond between the wound and the material. Bacterial biofilm infections are life-threatening. Clindamycin (Cly) can be produced in the form of a self-healing hydrogel preparation. It is noteworthy that the antibacterial self-healing hydrogels show great promise as a wound dressing for bacterial biofilm infection. In this study, we developed a polyvinyl alcohol/borax (PVA/B) self-healing hydrogel wound dressing that releases Cly. Four ratios of PVA, B, and Cly were used to make self-healing hydrogels: F1 (4%:0.8%:1%), F2 (4%:1.2%:1%), F3 (1.6%:1%), and F4 (4%:1.6%:0). The results showed that F4 had the best physicochemical properties, including a self-healing duration of 11.81 ± 0.34 min, swelling ratio of 85.99 ± 0.12%, pH value of 7.63 ± 0.32, and drug loading of 98.34 ± 11.47%. The B-O-C cross-linking between PVA and borax caused self-healing, according to FTIR spectra. The F4 formula had a more equal pore structure in the SEM image. The PVA/B-Cly self-healing hydrogel remained stable at 6 ± 2 °C for 28 days throughout the stability test. The Korsmeyer-Peppas model released Cly by Fickian diffusion. In biofilm-infected mouse wounds, PVA/B-Cly enhanced wound healing and re-epithelialization. Our results indicate that the PVA/B-Cly produced in this work has reliable physicochemical properties for biofilm-infected wound therapy.

## Keywords
- Self-healing hydrogels
- Polyvinyl alcohol
- Wound healing
- Biofilm
- Borax
- Materials science
- Self-healing
- Chemistry
- Composite material
- Polymer chemistry
- Medicine
- Surgery
- Bacteria
- Organic chemistry
- Genetics
- Biology
- Pathology
- Alternative medicine
- Raw material

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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