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Universitas Hasanuddin
Research output:Contribution to journal›Article›peer-review
Development and validation of a high-performance liquid chromatography method for levothyroxine sodium quantification in plasma for pre-clinical evaluation of long-acting drug delivery systems
Permana A.D.
Analytical Methods
Q2Published: 2021Citations: 10
Abstract
. The extraction recovery of LEVO in rat plasma samples by this method was between 80 and 85%. The method was selective, sensitive, accurate and precise for detecting and quantifying LEVO in a pharmacokinetic study carried out in rats for pre-clinical evaluation of long acting formulations. The validated HPLC method meets the ICH established requirements and therefore offers a wide range of potential applications in pre-clinical therapeutic drug monitoring, pharmacokinetics and toxicology.
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10.1039/d1ay01049bOther files and links
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PharmacokineticsSciences
ChromatographySciences
LevothyroxineSciences
High-performance liquid chromatographySciences
Drug deliverySciences
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