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Correlation of highly sensitive C-reactive protein with adipose tissue insulin resistance in individuals without diabetes: a cross-sectional study
Oktarina N.H.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Obesity triggers various metabolic and non-metabolic disorders and has become a major health problem. Obesity can cause low-grade chronic inflammation, thereby increasing the secretion of proinflammatory adipokines, adipokines and free fatty acids from adipose tissue. Adipose tissue insulin resistance (Adipo-IR) is an early metabolic defect in the development of insulin resistance that precedes insulin resistance in skeletal muscle and liver. An understanding of the pathogenesis of obesity, including its interaction with the inflammatory response, may provide better insights to prevent its complications. This study aims to analyze the correlation between Adipo-IR and highly sensitive C-reactive protein (hs-CRP) in both obese and non-obese individuals without diabetes.METHODS: A cross-sectional study was conducted using a sample of 33 non-diabetic participants with obesity and 33 non-diabetic participants without obesity. Samples were checked for Fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) to ensure they did not have diabetes mellitus (DM) and then grouped based on Body Mass Index. FPG and OGTT levels were checked using the enzymatic hexokinase method, hs-CRP levels were checked using the ELISA method, Adipo-IR value, which is the product of fasting insulin and FFA, fasting insulin levels were checked using the ECLIA method, FFA levels were checked using the ELISA method.RESULTS: The results showed that the mean levels of hs-CRP and Adipo-IR values were higher in non-DM participants with obesity than in non-DM participants without obesity (P≤0.05). There was a weak relationship between hs-CRP and Adipo-IR with the incidence of obesity and statistically significant (P≤0.05). However, there was no correlation between hs-CRP and Adipo-IR in non-DM participants with and without obesity.CONCLUSIONS: Mean hs-CRP levels and Adipo-IR values were higher in non-DM participants with obesity than in non-DM participants without obesity. There was an association between hs-CRP and Adipo-IR levels with the incidence of obesity, but there was no correlation between hs-CRP and Adipo-IR in non-DM participants.