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Correlation between thoracolumbal spinal cord traction and motor function in Wistar rats
Yudiarto D.A.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Spinal cord trauma is an injury affecting the cervical vertebra and lumbar. It is a major health problem, affecting 150,000-500,000 people in almost every country, with an estimated 10,000 new cases annually. However, no data indicates the degree to which spinal cord traction can cause sensory dysfunction in the thoracolumbar area. Therefore, this study aimed to assess the relationship between thoracolumbar spinal cord traction and motor function using a Wistar rat spinal cord trauma model.METHODS: This experimental study used a post-test design and comprised three treatment groups of nine rats. Group 1 was treated with a 0.5 mm traction mass, group 2 with a 1 mm traction mass, and group 3 with a 1.5 mm traction mass. Traction was performed for 24, 36, or 72 hours. Data groups were compared using Chi-square tests, considering a P<0.05 to be statistically significant.RESULTS: The post-traction mobility of 54 Wistar rats was assessed using gait and forced swim tests. At 24 hours, most rats had no plegia, followed by unilateral plegia and no bilateral plegia (P=0.024). At 48 hours, most rats had unilateral plegia, followed by no plegia and no bilateral plegia (P<0.001). At 72 hours, most rats had bilateral plegia, followed by unilateral plegia and no plegia (P<0.001).CONCLUSIONS: There was a significant relationship between the degree of spinal cord traction and motor function in the gait and forced swim tests at 24, 48, and 72 hours.