Correlation between HOMA-IRvalue and urinary albumin excretion rate in nondiabetic young adult subjects

Abstract

BACKGROUND: Several previous studies have proven the correlation between homeostatic model assessment of insulin resistance (HOMA-IR) values and increased urinary albumin excretion. However, these studies only examined the elderly or those with metabolic diseases. Moreover, hyperinsulinemia, or IR, occurs in elderly and young adults. IR in young adults can also cause an increase in urinary albumin excretion, which is a sign of renal impairment and cardiovascular complications. The purpose of this study was to determine the correlation between HOMA-IR values and urinary albumin excretion rates in nondiabetic young adults.METHODS: This retrospective cross-sectional study was conducted in February 2023 at the UNHAS Teaching Hospital Makassar. It involved 98 internal medicine residents in the Faculty of Medicine at Hasanuddin University aged 25-40 years and without diabetes mellitus and chronic kidney disease. IR was estimated by the HOMA-IR method. Albuminuria was measured by the urine albumin-to-creatinine ratio method.RESULTS: The HOMA-IR value was significantly correlated with the urinary albumin excretion rate (P=0.019), with the HOMA-IR value increasing with the urinary albumin excretion rate. Furthermore, male sex (P<0.05) and obesity (P<0.05) were also significantly associated with higher HOMA-IR values and urinary albumin excretion rates in nondiabetic young adults.CONCLUSIONS: HOMA-IR values were positively correlated with urine albumin excretion rates in nondiabetic young adult participants, which were both significantly associated with male sex and obesity.

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