# Comparison of serum and vitreous TGF-β1 levels in proliferative diabetic retinopathy with and without panretinal photocoagulation laser therapy
> Muhiddin H.S.

URL kanonis: https://discover.unhas.ac.id/publications/comparison-of-serum-and-vitreous-tgf-1-levels-in-proliferative-diabetic-retinopa
Jurnal / Konferensi: Bali Medical Journal
Tahun terbit: 2022
DOI: https://doi.org/10.15562/bmj.v11i1.3225
ISSN: 20891180
Citations: 3

## Authors
- Muhiddin H.S.

## Abstract
Introduction: A long-term diabetic retinopathy will cause an increase in several growth factors expression like Transforming Growth Factor β (TGF-β). This multipotent cytokine is involved in the process of endothelial cell proliferation. Therefore, this study aims to observe the relationship between TGF-β1 levels in serum and vitreous fluid of Proliferative Diabetic Retinopathy (PDR) patients given Pan Retinal Photocoagulation (PRP) laser therapy. Method: This was a cross-sectional study involving 14 patients with PDR. TGF-β1 levels of vitreous and peripheral blood were measured using Enzyme-linked Immunosorbent Assay (ELISA) method. The data were statistically analyzed using SPSS software for Windows ver. 23.0 for Mann-Whitney and the Spearman correlation test. Results: Our subjects consisted of 57.1% males with a mean age of 51.8 years, where dyslipidemia was the most common comorbid disease. Mean serum TGF-β1 level was 12,821.43 ± 5,253.16 pg/ml, while the mean value in vitreous was 3,692.86 ± 333.89 pg/ml. Meanwhile, there was no significant difference in serum and vitreous TGF-β1 levels between subjects with and without PRP laser therapy (p>0.05). Conclusion: There was no significant correlation between TGF-β1 levels in proliferative diabetic retinopathy patients with and without panretinal photocoagulation laser therapy. However, there was a decreasing trend in TGF-β1 levels in the vitreous fluid, indicating that PRP laser therapy has a positive effect on preventing the formation of neovascularization in the eye.

## Keywords
- Diabetic retinopathy
- Medicine
- Transforming growth factor
- Dyslipidemia
- Ophthalmology
- Neovascularization
- Diabetes mellitus
- Panretinal photocoagulation
- Transforming growth factor beta
- Internal medicine
- Growth factor
- Gastroenterology
- Endocrinology
- Angiogenesis
- Receptor

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.