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Comparison of clinical-pathological features, 5-year disease-free survival, and overall survival among various breast cancer hormone receptor statuses
Yahiji A.M.
Chirurgia Turin
Q4Abstract
BACKGROUND: Breast cancer (BC) is the most common malignancy among females worldwide and is characterized by varying hormone receptor statuses, which are crucial for prognosis and treatment. In Indonesia, BC remains a leading cause of female cancer-related deaths. The primary objective of this study was to analyze the relationships among estrogen receptor (ER) and progesterone receptor (PR) statuses and clinical-pathological features, overall survival (OS), and disease-free survival (DFS) in Indonesian breast cancer patients to understand how these hormone receptors affect prognoses and treatment outcomes.METHODS: A retrospective cohort observational analysis of 150 female breast cancer patients diagnosed from 2014 to 2016 was conducted at Dr. Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital in Makassar, Indonesia. Data were collected on the hormone receptor statuses, clinical stages, metastasis patterns, and histopathological grades of the patients. DFS and OS were measured over a five-year post-treatment period.RESULTS: The majority of patients were 50-59 years of age and in Stage IV at diagnosis. Bone metastasis was the most prevalent of all forms of metastasis. No significant correlation of ER/PR status with clinical stage or organ metastasis was found. However, a significant difference in DFS was noted among the various hormone receptor statuses, with ER+/PR+ patients showing good outcomes with a mean DFS of 43.12 months.CONCLUSIONS: While no significant correlations were found between hormone receptor status and clinical stages or metastasis patterns, the impact on DFS underscores the importance of hormone receptors in breast cancer prognoses. Future research should encompass comprehensive and longitudinal studies to fully understand the impact of hormone receptor status across various BC stages and populations.