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Comparison between colloid, ephedrine, and phenylephrine on hypotension occurrence in geriatric patients post-subarachnoid block
Gaus S.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Hypotension is a complication that might occur when subarachnoid block (SAB) is performed on geriatric patients. This study aimed to compare colloid fluid loading with ephedrine and phenylephrine pretreatment on the reduction in blood pressure after SAB.METHODS: This was a randomized, double-blinded, clinical trial conducted at Wahidin Sudirohusodo General Hospital and its network hospitals in Makassar, Indonesia from January to April 2024. Patients were divided into three groups: 1) patients who received colloid loading; 2) patients who received ephedrine premedication; and 3) patients who received phenylephrine premedication.RESULTS: Seventy-two patients participated in the study and were evenly distributed among three groups. The mean arterial pressure 15 minutes after spinal anesthesia was highest in the phenylephrine group compared to the other two groups, namely at the 5th, 6th, 8th, 10th, and 12th minute (P<0.05). The frequency of low blood pressure events was the least in the phenylephrine group when compared to the other groups (P<0.05). The occurrence of low blood pressure differed significantly between the ephedrine and phenylephrine groups when compared. (P=0.039).CONCLUSIONS: Phenylephrine pretreatment could prevent hypotension better than colloid loading or ephedrine pretreatment.