Comparative Analysis of Moringa Oleifera and Folic Acid in Preventing Liver Damage Induced by Acetaminophen in Rats; an Invivo Study

Abstract

A controlled in vivo study was conducted using a post-test-only control group design.Female Sprague Dawley rats (Rattus norvegicus) were induced with a toxic dose of acetaminophen (1000 mg/kgBW) and subsequently treated with Moringa Oleifera capsules and Folic Acid at doses of 150-200 mg/kgBW.SGOT and SGPT levels were measured to assess liver function.The data obtained were analyzed statistically, and the Kruskall-Wallis test was used.SGOT and SGPT levels were similar among experimental groups in the pretest phase, indicating that baseline liver enzyme levels were similar.Post-acetaminophen induction, SGOT, and SGPT levels varied little.These differences were statistically negligible (p > 0.05), suggesting all groups responded similarly to the hepatotoxic substance.After intervention, the Moringa Oleifera and Folic Acid (MO and AF) group had slightly higher liver enzyme levels than other groups.These changes were not significant (SGOT p = 0.071, SGPT p = 0.216).The MO and AF group showed a trend toward hepatoprotection, but these benefits were not statistically significant under the conditions evaluated.The study found that, while a trend shows that the combined Moringa Oleifera and Folic Acid (MO and AF) treatment may have hepatoprotective effects, these effects were not statistically significant under the experimental settings utilized.Neither Moringa Oleifera nor Folic Acid alone, nor in combination, effectively reduced acetaminophen-induced liver damage regarding SGOT and SGPT levels.These data suggest that further research is required to explore other dosages, treatment periods, or combinations to ascertain the definitive hepatoprotective efficacy of these drugs.

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