Share
Export Citation
Combination of 50% galam (Melaleuca cajuputi) leaf gel extract and tricalcium silicate cement as direct pulp capping materials: In vivo study
Nugroho J.J.
Aip Conference Proceedings
Abstract
One of the direct pulp capping materials is tricalcium silicate cement. This material has high biocompatibility and can induce odontoblast-like cells better than calcium hydroxide and MTA. Galam leaf has anti-inflammatory content and ability to induce TGF-β1, and thus it can improve the quality of tricalcium silicate cement when combined. We analyzed the effect of 50% galam (Melaleuca cajuputi subsp. Cumingiana barlow) leaf gel extract and tricalcium silicate cement mixture as direct pulp capping material on increasing the number of odontoblast-like cells on day 7 and day 14 compared to the control group. This research was a true experiment with posttest-only control design using 18 male Wistar rats which were divided into 6 groups: the group given 50% galam leaf gel extract and tricalcium silicate cement mixture, tricalcium silicate cement as a positive control, and a negative control without treatment. Rats were euthanized on days 7 and 14. The results of a two-way ANOVA test obtained p value=0.00, indicating a significant difference between each group and each day. Bonferroni’s Post Hoc test showed significant difference between galam leaf gel extract and tricalcium silicate cement mixture, tricalcium silicate cement, and no treatment on day 7 and day 14. It also showed a significant difference between the number of odontoblast-like cells on day 7 and day 14. Galam leaf gel extract and tricalcium silicate cement mixture have a better effect on increasing the number of odontoblast-like cells than tricalcium silicate cement and without treatment on days 7 and 14.