# CD133 Act as an Essential Marker in Ovarian Carcinogenesis
> Ikram D.

URL kanonis: https://discover.unhas.ac.id/publications/cd133-act-as-an-essential-marker-in-ovarian-carcinogenesis
Jurnal / Konferensi: Asian Pacific Journal of Cancer Prevention
Tahun terbit: 2021
DOI: https://doi.org/10.31557/APJCP.2021.22.11.3525
ISSN: 15137368
Kuartil SJR: Q2
Citations: 12

## Authors
- Ikram D.

## Abstract
Objective: To analyze the role of cancer stem cells (CSC) in ovarian carcinogenesis through the identification of CD133 expression in the normal ovary (NO), serous cystadenoma (SC), borderline serous tumour (BST), low-grade serous carcinoma (LGSC), and high-grade serous carcinoma (HGSC). Materials and methods: A total of 48 tissue samples contain 5 NO, 10 SC, 5 BST, 8 LGSC, and 20 HGSC were stained with anti-CD133 antibody by immunohistochemical protocol. The difference in the H-score of CD133 expression between groups and their relationship to age, histomorphology, and localization was analyzed. Results: CD133 expression varied among tumor groups, with clinicopathologic parameters showing diverse associations (age p = 0.773; histomorphology p = 0.001; and localization p = 0.026). The comparison of CD133 H-scores differed significantly between each group (p = 0.0031), in which precursor and malignant lesions possessed more robust CD133 expression. Conclusion: The presence of CD133 cellular expression and localization in different types of serous ovarian tumours suggests that these markers are involved in ovarian tumorigenesis.

## Keywords
- Serous fluid
- Immunohistochemistry
- Serous Cystadenoma
- Carcinogenesis
- Ovarian carcinoma
- Ovarian cancer
- Pathology
- Serous carcinoma
- Ovary
- Biology
- Cancer
- Medicine
- Cancer research
- Internal medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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