# Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum
> Linn T.Z.

URL kanonis: https://discover.unhas.ac.id/publications/cassane-and-norcassane-type-diterpenes-from-caesalpinia-crista-of-indonesia-and
Jurnal / Konferensi: Journal of Natural Products
Tahun terbit: 2005
DOI: https://doi.org/10.1021/np0401720
ISSN: 01633864
Kuartil SJR: Q1
Citations: 86

## Authors
- Linn T.Z.

## Abstract
The CH2Cl2 extract of the seed kernels of Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted in the isolation of seven new furanocassane-type diterpenes [caesalpinins C-G (1-5) and norcaesalpinins D and E (6, 7)] together with norcaesalpinins A-C (8-10) and 11 known compounds (norcaesalpinins A-C, 2-acetoxy-3-deacetoxycaesaldekarin e, caesalmin B, caesaldekarin e, caesalpin F, 14(17)-dehydrocaesalpin F, 2-acetoxycaesaldekarin e, 7-acetoxybonducellpin C, and caesalmin G). Their structures were determined on the basis of spectroscopic analysis. The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. Their IC50 values ranged from 90 nM to 6.5 microM, and norcaesalpinin E (7) showed the most potent inhibitory activity (IC50, 90 nM).

## Keywords
- Plasmodium falciparum
- Plasmodium berghei
- Stereochemistry
- In vivo
- In vitro
- IC50
- Traditional medicine
- Pharmacognosy
- Diterpene
- Chemistry
- Biology
- Biological activity
- Malaria
- Biochemistry
- Medicine
- Immunology
- Biotechnology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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