Can the Proinflammatory Cytokines IL-6 and TNF-α Act as Biomarkers of Autism Spectrum Disorder? A Literature Review

Abstract

Background: WHO reports that out of 160 children, one of them has autism spectrum disorder (ASD). Experts estimate that the cause of autism could be heavy metals. This review aims to assess the progress of research on the potential use of IL-6 and TNF-α cytokines as ASD biomarkers. Methods: This review uses sources from the PubMed and ScienceDirect databases. The keywords used were IL-6 AND TNF-α AND (Autism OR Autism Spectrum Disorder OR ASD). At the research identification stage, 63 studies were obtained, and after the screening, 12 studies were found that met the requirements for a review.

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