# Beneficial effects of probiotic supplementation (Lactiplantibacillus plantarum Dad-13) on body weight, liver function, and liver histopathological features in non-alcoholic fatty liver disease (NAFLD) model Sprague-Dawley rats
> Minhajat R.

URL kanonis: https://discover.unhas.ac.id/publications/beneficial-effects-of-probiotic-supplementation-lactiplantibacillus-plantarum-da
Jurnal / Konferensi: Bioscience of Microbiota Food and Health
Tahun terbit: 2025
DOI: https://doi.org/10.12938/bmfh.2024-131
ISSN: 21866953
Kuartil SJR: Q1
Citations: 0

## Authors
- Minhajat R.

## Abstract
Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder characterized by hepatic fat accumulation unrelated to alcohol consumption, with its prevalence rising alongside obesity rates. The gut-liver axis reveals that gut microbiota and metabolites significantly impact NAFLD development and progression. This study aimed to investigate the effects of probiotic <i>Lactiplantibacillus plantarum</i> Dad-13 on body weight, liver function, and histopathological features in a rat model of NAFLD. The experimental protocol involved administering probiotic <i>L. plantarum</i> Dad-13 at a dose of 3 × 10<sup>9</sup> CFU/g over six weeks to rats with NAFLD induced by a high-fat and high-fructose (HFFr) diet. The results demonstrated significant reductions in body and liver weight, improved liver function (serum lipopolysaccharide binding protein, aspartate aminotransferase, and alanine aminotransferase levels), and improved the non-alcoholic liver activity score in rats fed HFFr diets supplemented with probiotics. These findings suggest that supplementation with probiotic <i>L. plantarum</i> Dad-13 is a promising therapeutic intervention for NAFLD.

## Keywords
- Fatty liver
- Liver function
- Medicine
- Internal medicine
- Probiotic
- Gastroenterology
- Disease
- Body weight
- Biology
- Genetics
- Bacteria

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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