# Bacteria-targeted clindamycin loaded polymeric nanoparticles: Effect of surface charge on nanoparticle adhesion to MRSA, antibacterial activity, and wound healing
> Hasan N.

URL kanonis: https://discover.unhas.ac.id/publications/bacteria-targeted-clindamycin-loaded-polymeric-nanoparticles-effect-of-surface-c
Jurnal / Konferensi: Pharmaceutics
Tahun terbit: 2019
DOI: https://doi.org/10.3390/pharmaceutics11050236
ISSN: 19994923
Kuartil SJR: Q1
Citations: 105

## Authors
- Hasan N.

## Abstract
Adhesion of nanoparticles (NPs) to the bacterial cell wall by modifying their physicochemical properties can improve the antibacterial activity of antibiotic. In this study, we prepared positively charged clindamycin-loaded poly (lactic-co-glycolic acid)-polyethylenimine (PLGA-PEI) nanoparticles (Cly/PPNPs) and negatively charged clindamycin-loaded PLGA NPs (Cly/PNPs) and investigated the effect of NP adhesion to bacteria on the treatment of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)-infected wounds. The Cly/PPNPs and Cly/PNPs were characterized according to particle size, polydispersity index, surface charge, and drug loading. Both Cly/PPNPs and Cly/PNPs exhibited sustained drug release over 2 days. The Cly/PPNPs bind to the MRSA surface, thereby enhancing bactericidal efficacy against MRSA compared with the Cly/PNPs. Furthermore, compared with other groups, Cly/PPNPs significantly accelerated the healing and re-epithelialization of wounds in a mouse model of a MRSA-infected wounds. We also found that both NPs are harmless to healthy fibroblast cells. Therefore, our results suggest that the Cly/PPNPs developed in this study improve the efficacy of clindamycin for the treatment of MRSA-infected wounds.

## Keywords
- PLGA
- Adhesion
- Clindamycin
- Antibacterial activity
- Microbiology
- Chemistry
- Nanoparticle
- Antibiotics
- Bacteria
- Nanotechnology
- Materials science
- Organic chemistry
- Biochemistry
- Biology
- Genetics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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