# Asymptomatic plasmodial infection is associated with increased tumor necrosis factor receptor II-expressing regulatory T cells and suppressed type 2 immune responses
> Wammes L.J.

URL kanonis: https://discover.unhas.ac.id/publications/asymptomatic-plasmodial-infection-is-associated-with-increased-tumor-necrosis-fa
Jurnal / Konferensi: Journal of Infectious Diseases
Tahun terbit: 2013
DOI: https://doi.org/10.1093/infdis/jit058
ISSN: 00221899
Kuartil SJR: Q1
Citations: 24

## Authors
- Wammes L.J.

## Abstract
BACKGROUND: In malaria-endemic areas, a proportion of individuals becomes chronic carriers of parasites with few or no clinical signs. There is little information on cellular immune responses in asymptomatic parasite carriers. METHODS: In 80 schoolchildren residing in a malaria-endemic area of Flores Island, Indonesia, T-helper subsets, regulatory T-cell (Treg) frequencies, tumor necrosis factor receptor type II (TNFRII) expression on Tregs, and cytokine responses induced by Plasmodium falciparum-infected red blood cells (RBCs) were measured, and values for asymptomatic infected subjects were compared to those for uninfected controls. To ascertain that alterations found were due to the presence of malaria parasites, the immune responses were analyzed in 16 children before and 1 month after antimalarial treatment. RESULTS: TNFRII expression, a marker of activation on Tregs, was higher during infection but decreased upon treatment. GATA3-positive cells and the level of interleukin 13 secretion in response to P. falciparum-infected RBCs appeared to be suppressed by plasmodial infection, as both increased after antimalarial treatment. TNFRII expression on Tregs correlated positively with TNF in response to P. falciparum-infected RBCs, but this association disappeared following treatment. CONCLUSIONS: Malaria parasites associated with asymptomatic infections seem to result in increased TNFRII expression on Tregs, as well as suppressed Th2 cytokine responses, features that might be important for survival of the parasites in asymptomatic carriers.

## Keywords
- Asymptomatic
- Immunology
- Immune system
- Malaria
- Tumor necrosis factor alpha
- Cytokine
- Plasmodium falciparum
- Asymptomatic carrier
- Biology
- Medicine
- Internal medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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