# Association between vitamin D levels with IL-6 and IL-10 in umbilical cord blood of infants
> Massi M.N.

URL kanonis: https://discover.unhas.ac.id/publications/association-between-vitamin-d-levels-with-il-6-and-il-10-in-umbilical-cord-blood
Jurnal / Konferensi: Narra J
Tahun terbit: 2024
DOI: https://doi.org/10.52225/narra.v4i3.889
ISSN: 28072618
Kuartil SJR: Q2
Citations: 3

## Authors
- Massi M.N.

## Abstract
A worldwide issue, vitamin D deficiency affects pregnant mothers and babies everywhere, including Indonesia. It involves the adaptive immune system by controlling the production of pro-and anti-inflammatory cytokines and the balance between humoral (Th2) and cell-mediated (Th1) immunity. The aim of this study was to investigate the relationship between vitamin D and the cytokines IL-6 and IL-10 in infants. It also examined the relationship between ferritin and IL-6/IL-10 in newborns. The study collected 114 umbilical cord blood samples from term-born mothers without clinical symptoms. IL-6 and IL-10 were among the cytokine profiles measured by the enzyme-linked immunosorbent assay (ELISA). SPSS was used for statistical analysis, and an in -silico investigation was carried out to examine the molecular relationships between vitamin D and IL-6/IL-10. Using the 20 ng/mL as the cut-off for vitamin D insufficiency suggested the insignificant association of vitamin D with IL-6 (<i>p</i>=0.42), IL-10 (<i>p</i>=0.76), and ferritin (<i>p</i>=0.47). When the umbilical cord vitamin D level was categorized into four quartiles, the association with the highest statistical significance (quartile 4 versus quartile was observed for IL-6 (<i>p</i><0.001), IL-10 (<i>p</i><0.001), and ferritin (<i>p</i><0.001). However, the linear regression did not suggest the significant correlations of vitamin D with IL-6 (<i>p</i>=0.40) and IL-10 (<i>p</i>=0.45). A significant correlation based on the linear regression was found between ferritin and IL-10 (<i>p</i>=0.03). Molecular docking studies demonstrated binding affinities of -8.04 kcal/mol for IL-6-vitamin D and -8.53 kcal/mol for IL-10 -vitamin D complexes, with stable root mean square deviation throughout the simulations. This study contributes valuable insights into the clinical and computational analysis of the relationship of vitamin D with IL-6 or IL-10.

## Keywords
- Vitamin D and neurology
- Umbilical cord
- Medicine
- Ferritin
- Quartile
- vitamin D deficiency
- Immune system
- Internal medicine
- Statistical significance
- Cord blood
- Immunology
- Cytokine
- Endocrinology
- Physiology
- Confidence interval

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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