# Association between serum interleukin-6 levels with the risk and clinical severity of primary open-angle glaucoma
> Ulhaq Z.S.

URL kanonis: https://discover.unhas.ac.id/publications/association-between-serum-interleukin-6-levels-with-the-risk-and-clinical-severi
Jurnal / Konferensi: Expert Review of Ophthalmology
Tahun terbit: 2021
DOI: https://doi.org/10.1080/17469899.2021.1990758
ISSN: 17469899
Kuartil SJR: Q3
Citations: 11

## Authors
- Ulhaq Z.S.

## Abstract
Objectives To clarify the association between serum levels of interleukin (IL)-6 with the risk and clinical severity of primary open-angle glaucoma (POAG).Methods A case–control study was performed in 78 participants (40 POAG cases and 38 controls). The serum level of IL-6 was then quantified by enzyme-linked immunosorbent assay (ELISA). A meta-analysis was conducted from available studies investigating serum IL-6 levels in POAG and controls.Results We found that serum IL-6 level was significantly higher in POAG cases (32.24 ± 14.42 pg/mL) than the controls (14.36 ± 6.89 pg/mL, p < 0.0001), which was also confirmed by pooled analysis (mean difference (MD) 5.977 ng/mL (95% CI = (95% confidence interval (CI) = 0.979–10.975; p = 0.019). Our finding also indicated the association between elevated level of serum IL-6 and risk (OR = 48, 95% CI = 12.42–185.49, p = <0.0001) and severity (OR = 4.33, 95% CI = 1.15–16.32, p = 0.030) of POAG.Conclusion Serum IL-6 level plays a crucial role in the pathogenesis and severity of POAG.

## Keywords
- Medicine
- Confidence interval
- Internal medicine
- Open angle glaucoma
- Gastroenterology
- Pathogenesis
- Interleukin 6
- Glaucoma
- Case-control study
- Ophthalmology
- Cytokine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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