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Association between MSH2 expression and clinicopathological aspects in patients with colorectal cancer at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia
Pratiwi Y.
Chirurgia Turin
Q4Abstract
BACKGROUND: Colorectal cancer (CRC) is a malignant neoplastic carcinoma of the colon or rectum that has considerable metastatic potential. Recently, MutS homolog 2 (MSH2) has been indicated as a promising molecular biomarker for CRC. The objective of this study was to investigate the association between MSH2 expression and clinicopathological features in patients diagnosed with CRC.METHODS: This observational analysis and cross-sectional study evaluated MSH2 expression in 45 tissue samples from CRC patients using the immunohistochemistry method. Demographic, staging, histopathological grading, CRC location, and blood type data were collected. The relationship between MSH2 expression status and clinicopathological features was analyzed utilizing Fisher’s Exact Test, the Mann-Whitney U Test, and the Kolmogorov-Smirnov Test (P<0.05).RESULTS: A total of 82.2% of the research participants exhibited positive MSH2 expression results. Bivariate analysis showed a significant association of tumor location (P=0.001), cancer stadium (P=0.021), and tumor grading (P=0.001) with MSH2 expression in patients diagnosed with CRC. No significant association was identified between patient sex, age, or blood type and MSH2 expression.CONCLUSIONS: The majority of the CRC patients exhibited positive MSH2 expression. Significant associations existed between MSH2 expression and CRC clinical characteristics such as tumor location and grading and CRC stage.