Antidiabetic Potential and Mechanism of Action Exploration of Sulawesi Ethnopharmacological Agents: In vitro Screening

Abstract

The research involved the extraction and in vitro screening of bioactive compounds from several plant samples. The extraction process yielded the following extract percentages: Antidesma bunius (2.28%), Cordia myxa (1.93%), Syzygium cumini (1.87%), and Syzygium malacense (2.97%). Subsequently, each sample was fractionated using n-hexane, ethyl acetate, and methanol. The extracts and fractions were then tested in vitro for their inhibitory activity against α-glucosidase enzyme using a microplate reader. The findings revealed that all extracts demonstrated notable inhibitory activity, with IC50 values of 5.66 ppm, 6.03 ppm, 6.17 ppm, and 6.13 ppm respectively. Importantly, these values are lower than the IC50 of the standard drug, Acarbose (6.85 ppm), highlighting the superior α-glucosidase inhibitory potential of the plant extracts. This indicates their promise as natural antidiabetic agents.

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