# Antibacterial and anti-inflammatory effects of lime (Citrus aurantifolia) peel extract in Balb/c mice infected by Salmonella typhi
> Kasim V.N.

URL kanonis: https://discover.unhas.ac.id/publications/antibacterial-and-anti-inflammatory-effects-of-lime-citrus-aurantifolia-peel-ext
Jurnal / Konferensi: Journal of Biological Research Italy
Tahun terbit: 2020
DOI: https://doi.org/10.4081/JBR.2020.8951
ISSN: 18268838
Kuartil SJR: Q4
Citations: 5

## Authors
- Kasim V.N.

## Abstract
Lime (Citrus aurantifolia) is a traditional plant that is widely used as antibacterial. This study proves the effect of Lime Peel Extract (LPE) on the colonization and growth, mediated by the activity of IL-6, of bacteria Salmonella typhi in Balb/c mice. Mice were divided into four groups; LPE 510 mg/kg body weight (bw), LPE 750 mg/kgbw, and positive and negative control. The examination was carried out 3 times, on the 5th day before the intervention, on the 10th day after the intervention and on the 30th day after maintenance. Intervention of LPE for 5 days can decrease the number of S. typhi colonies, even maintenance for 20 days after the intervention showed no bacterial growth. IL-6 pro-inflammatory cytokine activity increased on examination day 5 after S. typhi injection and decreased after intervention on day 10, it was significantly different between pre and post at all groups except for negative controls (p=0.15). The speed of decrease in IL-6 levels was the greatest at the LPE 750 mg/kgbw (velocity=-5.64%). LPE decreased serum levels of IL-6 and inhibited the growth of S. typhi colony in Balb/c mice. LPE has potential for antibacterial and anti-inflammatory.

## Keywords
- Salmonella typhi
- Microbiology
- Antibacterial activity
- Biology
- Traditional medicine
- Bacteria
- Medicine
- Biochemistry
- Escherichia coli
- Genetics
- Gene

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.