Anti-aging properties of extracts from Ziziphus mauritiana leaves. A comprehensive systematic review and meta-analysis

Abstract

With growing awareness of the transformations occurring in the body due to aging, these changes have become the subject of research by many scientists. Attempts are being made to halt this process naturally, using the potential of various herbs. This study aimed to present the potency of extracts from the leaves of the plant Ziziphus mauritiana as an anti-aging agent, by its antioxidant and anti-inflammatory properties. A systematic review and meta-analysis were performed using the PRISMA guidelines based on studies retrieved from PubMed, Science Direct, and the Cochrane Library that met the inclusion criteria up to March 2025. Variables, including antioxidant, anti-inflammatory, and anti-aging properties, were extracted and then analyzed descriptively and quantitatively. The study demonstrated the potential of Ziziphus mauritiana leaf extract to increase endogenous antioxidants, inhibit inflammation, increase collagen density, elasticity, hydration, and skin brightness, and reduce sebum levels, erythema, fibroblast numbers, and improve wound healing.

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