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Angiotensin II and asymmetric dimethylarginine in normotensive young adults with offspring of essential hypertension
Palar S.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: It has been reported that abnormal activation of the renin-angiotensin-aldosteron-system (RAAS) and subsequent endothelial dysfunction is associated with the early pathophysiology of hypertension. Endothelial dysfunction will increase the expression of adhesion molecules, such as asymmetric dimethylarginine (ADMA). This study was aimed to observe the association between levels of serum angiotensin II and ADMA in normotensive young adults which offspring of essential hypertension.METHODS: This observational analytic, cross-sectional study was observed the difference of variables levels between normotensive young adults which offspring of essential hypertension (case group) and without offspring hypertension (control group). Data were recruited by consecutive sampling and analyzed by univariate and the Mann-Whitney, unpaired t-tests. The significance level is 95% (P<0.05).RESULTS: There were 25 cases with mean of age 28.88±3.59 years old, BMI 23.96±3.11 kg/m2, angiotensin II 4.44±5.64 pg/mL, ADMA 0.72±0.22 μmol/L and 25 controls with mean of age 28.92±3.87 years old, BMI 22.67±2.16 kg/m2, angiotensin II 2.24±1.05 pg/mL, ADMA 0.82±0.20 μmol/L. The level of angiotensin II of normotensive young adults which offspring of essential hypertension was significantly higher than without offspring hypertension (P=0.01). However, there was no significant difference of ADMA levels between normotensive young adults which offspring of essential hypertension and without offspring hypertension (t(48)=1.74, P=0.09).CONCLUSIONS: This study showed, the angiotensin II in normotensive young adults which offspring of essential hypertension was significantly higher than normotensive without offspring hypertension. Understanding the early risk of hypertension is important to provide the prevention strategies.