# Analysis of serum homocysteine reference range value in a population of healthy young adults
> Tahir M.

URL kanonis: https://discover.unhas.ac.id/publications/analysis-of-serum-homocysteine-reference-range-value-in-a-population-of-healthy
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2025
DOI: https://doi.org/10.23736/S0393-3660.24.05745-0
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Tahir M.

## Abstract
BACKGROUND: Homocysteine is a demethylated derivative of the essential amino acid, methionine. Homocysteine undergoes transulphuration via cystathionin to form cysteine. The conversion of homocysteine to cystathionin is catalyzed by cystathionine ß synthase (CBS), which requires pyridoxal five phosphate (P5P) as the active form of vitamin B6 or as a cofactor. In humans, there are at least two pathways for the remethylation of homocysteine to methionine. This reaction requires folic acid and vitamin B12. This study aimed to determine the reference range for serum homocysteine levels in healthy young adults.METHODS: Data from 120 subjects consisting of 60 men and 60 women with an average age of 31 years were examined using the Enzymatic Assay method with a Cobas C311® instrument with a measurement range of 350 µmol/L. The lower measurement limit was blank = 3 µmol/L (95% probability), detection limit = 3 µmol/L, and quantity limit = 5.5 µmol/L.RESULTS: Research shows that the reference range for serum homocysteine levels in healthy young adults was 5. 94-14.85 µmol/L, in men it is 6.29-15.08 µmol/L and in women it is 5.75-14.31 µmol/L.CONCLUSIONS: The reference range values for serum homocysteine levels in a healthy young adult population were by the reference ranges reported in other countries.

## Keywords
- Homocysteine
- Reference range
- Young adult
- Medicine
- Cystathionine beta synthase
- Pyridoxal
- Population
- Plasma homocysteine
- Endocrinology
- Methionine
- Internal medicine
- Vitamin
- Hyperhomocysteinemia
- Folic acid
- Reference values
- Pyridoxine
- Chemistry
- Detection limit
- Population study
- Biochemistry
- Limit (mathematics)
- Cobalamin
- Physiology
- Range (aeronautics)
- Value (mathematics)
- Confidence interval

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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