# An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder [Letter]
> Safitri N.

URL kanonis: https://discover.unhas.ac.id/publications/an-effect-of-chronic-negative-stress-on-hippocampal-structures-and-functional-co
Jurnal / Konferensi: Neuropsychiatric Disease and Treatment
Tahun terbit: 2024
DOI: https://doi.org/10.2147/NDT.S478851
ISSN: 11782021
Kuartil SJR: Q2
Citations: 0

## Authors
- Safitri N.

## Abstract
Structures and Functional Connectivity in Patients with Depressive Disorder. Depressive disorder is a condition that causes patients to have symptoms of poor mood, increased fatigue and anhedonia and deficits in neurocognitive functions, such as impaired memory, visuo-spatial processing and attention. The hippocampus is a brain structure that is involved in stress processing and also depressive disorders if they experience changes in volume are therefore very important to improve our understanding of mental disorders related to the structure of the hippocampus. he study conducted by Lili Zhang et al used the Diagnostic and Statistical Manual of Mental Disorders 5th to diagnose patients with major depressive disorder, the Life Events Scale (LES) to evaluate chronic negative stress from patients and collected fMRI data to look at hippocampal volume. In addition, we also recommend that additional information regarding the duration of symptoms, psychopharmacological treatment and previous psychotherapy be provided by the patients themselves. The opposite is found in patients who do not experience chronic negative stress. 1 However, it should be noted that the pattern of hippocampal volume in stress, PTSD and MDD may indicate that the hippocampus may represent a different phenotype than traditional diagnostic strategies so it is important to know the patient's history such as treatment. During treatment, duration of illness and drug interventions to reflect the pathophysiology and mechanisms of all psychiatric disorders.

## Keywords
- Medicine
- Hippocampal formation
- Chronic stress
- Functional connectivity
- Neuroscience
- Major depressive disorder
- Psychiatry
- Bioinformatics
- Internal medicine
- Cognition
- Biology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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