AGGREGATE INDEX OF SYSTEMIC INFLAMMATION (AISI) IN SURVIVOR AND NON-SURVIVOR SEPSIS PATIENTS

Abstract

Sepsis is a serious condition characterized by organ dysfunction resulting from an inappropriate immune response to infection. It is one of the primary causes of death and illness among critically ill patients, and its occurrence has risen over the past century. Aggregate Index of Systemic Inflammation (AISI) is a new method considered in the progression and diagnosis of various infections and inflammatory diseases based on routine blood test results. To compare the AISI values in sepsis survivors and non-survivors on the first and seventh day. Retrospective study of 355 sepsis patients consisting of 205 sepsis non-survivors and 150 sepsis survivors who were admitted to Wahidin Sudirohusodo Hospital from January 2021 to December 2023. The first-and-seventh-day routine blood results obtained from the patient's medical record were used to calculate the AISI value. The median first day AISI score was significantly lower in sepsis non-survivors than in sepsis survivors (2,190.58 vs. 2,973.67) with p <0.05. The median value of seventh day AISI was significantly lower in non-survivor sepsis patients than in survivor sepsis patients (1,150.93 vs. 1,591.84), with p <0.05. Non-survivor and survivor sepsis patients had a significant decrease in AISI values on day 7 compared to day 1 (p <0.001). There was a significant difference in AISI values in sepsis survivor and non-survivor patients. AISI values were found to be higher in sepsis survivors on days 1 and 7 compared to sepsis non-survivors. AISI values were found to decrease more on day seven than on day one in both groups.

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