# Activity of antimicrobial peptide; cathelicidin, on bacterial infection
> Febriza A.

URL kanonis: https://discover.unhas.ac.id/publications/activity-of-antimicrobial-peptide-cathelicidin-on-bacterial-infection
Jurnal / Konferensi: Open Biochemistry Journal
Tahun terbit: 2019
DOI: https://doi.org/10.2174/1874091X01913010045
ISSN: 1874091X
Kuartil SJR: Q4
Citations: 18

## Authors
- Febriza A.

## Abstract
Antimicrobial peptide is an effector molecule from the natural immune system which plays a central role in defense as an antimicrobial. Cathelicidin is one of the antimicrobial peptides. Human only has one cathelicidin antimicrobial peptide called LL-37 or hCAP18. The detailed mechanism on CAMP (Cathelicidin Antimicrobial Peptide) gene regulation is still unknown, however, cathelicidin is found to have upregulation when there is bacterial infection. The most effective expression inducer of CAMP gene is 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), which is the active form of vitamin D. Vitamin D mediates cathelicidin synthesis through the expression of Vitamin D Receptor (VDR), then the interaction activates CAMP gene to express cathelicidin. The work mechanisms of cathelicidin against bacterial infection include damaging the bacterial cell membrane, inducing autophagy process of macrophage cell, neutralizing LPS produced by bacteria, and chemotactic activities of PMNs, monocytes and lymphocytes.

## Keywords
- Cathelicidin
- Antimicrobial
- Antimicrobial peptides
- Biology
- Innate immune system
- Microbiology
- Calcitriol receptor
- Peptide
- Immune system
- Cell biology
- Receptor
- Biochemistry
- Immunology

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.