# Activity and Kinetics of α-Glucosidase Inhibition by Collagen Hydrolysate from Thunnus albacares Bone
> Natsir H.

URL kanonis: https://discover.unhas.ac.id/publications/activity-and-kinetics-of-glucosidase-inhibition-by-collagen-hydrolysate-from-thu
Jurnal / Konferensi: Journal of Physics Conference Series
Tahun terbit: 2019
DOI: https://doi.org/10.1088/1742-6596/1341/3/032015
ISSN: 17426588
Citations: 8

## Authors
- Natsir H.

## Abstract
Abstract Controlling of postprandial hyperglycemia using α-glucosidase inhibitors is one of the therapeutic approaches for the treatment of type 2 diabetes. Collagen hydrolysate, as an α-glucosidase inhibitor has not been reported. Therefore, This study intends to evaluate the activity and kinetics of inhibition of collagen hydrolysate against the α-glucosidase enzyme. Collagen hydrolysate was prepared from Thunnus albacares bone enzymatically using bacterial collagenase at hydrolysis times (0; 0.5; 1; 2; 3; 4; 5 and 6 h). The type of inhibition was determined by enzyme kinetics analysis. Collagen hydrolysate obtained at hydrolysis time of 1 h has the highest inhibitory activity of 24.47 %. Based on enzyme kinetics analysis, collagen hydrolysate showed a show a type of competitive inhibition. These results revealed that collagen hydrolysate has the potential as a natural antidiabetic in controlling blood glucose levels in type 2 diabetes.

## Keywords
- Hydrolysate
- Chemistry
- Hydrolysis
- Collagenase
- Biochemistry
- Kinetics
- Enzyme kinetics
- Enzyme
- Food science
- Chromatography
- Active site
- Quantum mechanics
- Physics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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