# 1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk
> Crawford J.E.

URL kanonis: https://discover.unhas.ac.id/publications/1206-genomes-reveal-origin-and-movement-of-aedes-aegypti-driving-increased-dengu
Jurnal / Konferensi: Science
Tahun terbit: 2025
DOI: https://doi.org/10.1126/science.ads3732
ISSN: 00368075
Kuartil SJR: Q1
Citations: 7

## Authors
- Crawford J.E.

## Abstract
The emergence and global expansion of <i>Aedes aegypti</i> puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovirus control are unclear. We sequenced 1206 genomes from 73 globally distributed locations. After evolving a preference for humans in Sahelian West Africa, the invasive subspecies <i>Ae. aegypti aegypti</i> (<i>Aaa</i>) emerged in the Americas after the Atlantic slave trade era and expanded globally. Recent back-to-Africa <i>Aaa</i> migration introduced insecticide resistance and anthropophily into regions with recent dengue outbreaks, raising concern that <i>Aaa</i> movement could increase arbovirus risk in urban Africa. These data underscore developing complexity in the fight against dengue, Zika, and chikungunya and provide a platform to further study this important mosquito vector.

## Keywords
- Arbovirus
- Chikungunya
- Dengue fever
- Subspecies
- Biology
- Dengue virus
- Alphavirus infection
- Geography
- Genome
- Aedes
- Gene flow
- Arbovirus Infections
- Aedes aegypti
- Ecology
- Yellow fever
- Phylogeography
- Evolutionary biology
- Zoology
- Virology
- Resistance (ecology)
- Zika virus
- Mosquito control
- Movement (music)

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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